LB1042 Neuroimmune mediators of pruritus in scalp psoriatic itch: An immunofluorescent analysis in a Hispanic population

Background: Scalp psoriatic itch is a prevalent yet understudied condition with numerous associated treatment challenges. Objective: The current study aims to enhance our understanding of scalp pathophysiology in order guide management and identify novel targets. Methods: Immunohistochemical analysis known neuroimmune mediators pruritus was conducted using biopsies from 27 patients psoriasis. Patients were grouped per their NRS rating (taken at time biopsy) into mild (NRS 1-3), moderate 4-6), severe 7-10). Results: Intraepidermal nerve fiber (IENF) density, Substance P (SP), PAR2, TRPV3, TRPM8, IL-23 expression all significantly elevated psoriasis compared correlated intensity. TRPV1, TNFα, IL17 increased but did not correlate Conclusion: Our results are congruent prior data that largely non-histaminergic rather, driven by Type 1 IL-17 dominant immune response. Additionally, may have greater neurological component than previously thought.